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During the more than four decades
that RARAF has been in operation, experiments have been performed for over
50 different research groups from more than 40 institutions including universities,
national laboratories, cancer centers, and private corporations. These experiments,
performed with particulate radiations such as protons, alpha particles and
neutrons, have resulted in more than 200 publications in refereed journals,
proceedings, and books. Research has been conducted in the fields of radiation
biology, radiological physics, radiation chemistry, health physics, and
medicine.
Biology articles involving outside users
Bertucci, A., Pocock, R.D., Randers-Pehrson, G. and Brenner,
D.J. Microbeam irradiation of the C. elegans nematode. J Radiat
Res (Tokyo) 50 Suppl A: A49-54, (2009).
[abstract][PDF]
Bailey S.M. Michael Fry Research Award lecture: Telomeres
and double-strand breaks - all's well that "ends" well. Radiat Res.
169: 1-7 (2008).
[abstract][PDF]
Bailey S.M. and Cornforth M.N. Telomeres and DNA double-strand
breaks: ever the twain shall meet? Cell Mol Life Sci. 64:
2956-2964 (2007). [abstract][PDF]
Li H., Gu Y., Miki J., Hukku B., McLeod D.G., Hei T.K. and
Rhim JS. Malignant transformation of human benign prostate epithelial
cells by high linear energy transfer alpha-particles. Int J Oncol.
31: 537-544 (2007).
[abstract]
Koh E.S., Tran T.H., Heydarian M., Sachs R.K., Tsang R.W.,
Brenner D.J., Pintilie M., Xu T., Chung J., Paul N., Hodgson D.C., A comparison
of mantle versus involved-field radiotherapy for Hodgkin's lymphoma: reduction
in normal tissue dose and second cancer risk. Radiat Oncol. 2:
13 (2007). [abstract][PDF]
Miller A.C., Stewart M., Rivas R., Marino S., Randers-Pehrson
G., and Shi L., Observation of radiation-specific damage in cells exposed
to depleted uranium: hprt gene mutation frequency. Radiat. Meas.
42: 1029-1032 (2007).
[PDF]
Sedelnikova O.A., Nakamura A., Kovalchuk O.,Koturbash I.,
Mitchell S.A., Marino S.A., Brenner D.J., Bonner W.M., DNA double-strand
breaks form in bystander cells after microbeam irradiation of three-dimensional
human tissue models. Cancer Res. 67: 4295-4302 (2007).
[abstract]
[PDF]
Williams E.S., Stap J., Essers J., Ponnaiya B., Luijsterburg
M.S., Krawczyk P.M., Ullrich R.L., Aten J.A. and Bailey S.M., DNA double
strand breaks are not sufficient to initiate the recruitment of TRF2.
Nat. Genet 39: 696-698 (2007).[PDF]
Zhou H., Xu A., Gillispie J.A., Waldren C.A. and Hei T.K.
Quantification of CD59(-) mutants in human-hamster hybrid (A(L)) cells
by flow cytometry. Mutat. Res. 594: 113-119
(2006).[abstract]
[PDF]
Smilenov L.B., Hall E.J., Bonner W.M. and Sedelnikova O.A.
A microbeam study of DNA double-strand breaks in bystander primary human
fibroblasts. Radiat. Prot. Dosimetry 122: 256-259
(2006). [abstract][PDF]
Hu B., Wu L., Han W., Zhang L., Chen S., Xu A., Hei T.K.
and Yu Z. The time and spatial effects of bystander response in mammalian
cells induced by low dose radiation. Carcinogenesis
27:245-251 (2006). [abstract]
[PDF]
Amundson S.A., Do K.T., Vinikoor L., Koch-Paiz C.A., Bittner M.L., Trent
JM, Meltzer P and Fornace AJ Jr. Stress-specific signatures: Expression
profiling of p53 wild-type and null human cells. Oncogene
24:4572-4579 (2005). [abstract]
[PDF]
Calaf G.M., Emenaker N.J. and Hei T.K. Effect of
retinol on radiation- and estrogen-induced neoplastic transformation of
human breast epithelial cells. Oncol Rep 13:1017-1027
(2005). [abstract]
[PDF]
Hall E.J., Brenner D.J., Worgul B. and Smilenov L.
Genetic susceptibility to radiation. Adv Space Res 35:249-253
(2005). [abstract]
[PDF]
Hu B., Han W., Wu L., Feng H., Liu X., Zhang L., Xu
A., Hei T.K. and Yu, Z. In situ visualization of DSBs to assess the
extranuclear/extracellular effects induced by low-dose alpha-particle
irradiation. Radiat Res 164:286-291 (2005).
[abstract]
[PDF]
Miller, A.C., Beltran, D., Rivas, R., Stewart, M., Merlot,
M.J. and Lison, P.B. Radiation- and depleted uranium-induced carcinogenesis
studies: Characterization of the carcinogenic process and development
of medical countermeasures. The NATO Human Factors and Medicine Panel
Research Task Group 099 "Radiation Bioeffects and Countermeasures" meeting,
Bethesda, MD. June 21-23, 2005, AFFRI CD 05-2 (2005).
[PDF]
Sokolov M.V., Smilenov L.B., Hall E.J., Panyutin I.G.,
Bonner W.M. and Sedelnikova O.A. Ionizing radiation induces DNA
double-strand breaks in bystander primary human fibroblasts. Oncogene
24:7257-7265 (2005). [abstract]
[PDF]
Vives S., Loucas B., Vazquez M., Brenner D.J., Sachs R.K., Hlatky L.,
Cornforth M. and Arsuaga J. SCHIP: statistics for chromosome interphase
positioning based on interchange data. Bioinformatics 21:3181-3182
(2005). [abstract]
[PDF]
Worgul B.V., Smilenov L., Brenner D.J., Vazquez M. and Hall E.J. Mice
heterozygous for the ATM gene are more sensitive to both X-ray and heavy
ion exposure than are wildtypes. Adv Space Res 35:254-259
(2005). [abstract]
[PDF]
Zhou H., Suzuki M., Persaud R., Gillispie
J., Randers-Pehrson G. and Hei T.K. Contribution of bystander effects
in radiation induced genotoxicity. Acta Medica Nagasakiensia 50:73-77
(2005). [PDF]
Arsuaga J., Greulich-Bode K.M., Vazquez M., Bruckner M., Hahnfeldt P.,
Brenner D.J., Sachs R. and Hlatky, L. Chromosome spatial clustering
inferred from radiogenic aberrations. Int J Radiat Biol 80:507-515
(2004). [abstract]
[PDF]
Mitchell C.R., Azizova T.V., Hande M.P., Burak L.E.,
Tsakok J.M., Khokhryakov V.F., Geard C.R. and Brenner D.J. Stable
intrachromosomal biomarkers of past exposure to densely ionizing radiation
in several chromosomes of exposed individuals. Radiat Res 162:257-263
(2004). [abstract]
[PDF]
Mitchell S.A., Marino S.A., Brenner D.J. and Hall E.J.
Bystander effect and adaptive response in C3H 10T(1/2) cells. Int J
Radiat Biol 80:465-472 (2004).
[abstract]
[PDF]
Suzuki M., Zhou H., Hei T.K., Tsuruoka C. and Fujitaka K.
Effects of irradiated medium on chromatid aberrations in mammalian cells
using double mylar dishes. Biol Sci Space 18:110-111 (2004).
[abstract]
Zhao Y., Shao G., Piao C.Q., Berenguer J. and Hei T.K.
Down-regulation of Betaig-h3 gene is involved in the tumorigenesis in
human bronchial epithelial cells induced by heavy-ion radiation. Radiat
Res 162:655-659 (2004). [abstract]
[PDF]
Zhou H., Randers-Pehrson G., Waldren C.A. and Hei T.K.
Radiation-induced bystander effect and adaptive response in mammalian
cells. Adv Space Res 34:1368-1372 (2004).
[abstract]
[PDF]
Amundson SA, Bittner M and Fornace AJ, Jr. Functional genomics as a window on radiation stress
signaling. Oncogene 22:5828-5833 (2003). [abstract]
[PDF]
Fowler J.F., Ritter M.A., Chappell R.J. and Brenner D.J. What
hypofractionated protocols should be tested for prostate cancer? Int.
J. Radiat. Oncol. Biol. Phys. 56:1093-1104 (2003).
[abstract]
[PDF]
Hande M.P., Azizova T.V., Geard C.R., Burak L.E.,
Mitchell C.R., Khokhryakov V.F., Vasilenko E.K. and Brenner D.J. Past
exposure to densely ionizing radiation leaves a unique permanent signature
in the genome. Am. J. Hum. Genet. 72:1162-1170 (2003). [abstract]
[PDF]
Cornforth M.N., Greulich-Bode K.M., Loucas B.D., Arsuaga J., Vazquez
M., Sachs R.K., Bruckner M., Molls M., Hahnfeldt P., Hlatky L. and Brenner
D.J. Chromosomes are predominantly located randomly with respect to each
other in interphase human cells. J Cell Biol. 159:237-244
(2002). [abstract]
[PDF]
Morgan W.F., Hartmann A., Limoli C.L., Nagar S. and
Ponnaiya B. Bystander effects in radiation-induced genomic instability.
Mutat. Res. 504:91-100 (2002). [abstract]
[PDF]
Zhou H., Randers-Pehrson G., Suzuki M.,
Waldren C.A. and Hei T.K. Genotoxic damage in non-irradiated cells:
contribution from bystander effect. 13th Symposium on Microdosimetry,
Stresa, Italy, May 26-June 1, 2001. Radiat. Prot. Dosim. 99:227-232
(2002). [abstract]
[PDF]
Zhou H., Suzuki M., Geard
C.R. and Hei T.K. Effects of irradiated medium with or without cells on
bystander cell responses. Mutat. Res. 499:135-141 (2002). [abstract]
[PDF]
Zhou H., Xu A., Suzuki K.,
Randers-Pehrson G., Waldren C.A., Hall E.J. and Hei T.K. The Yin and Yan
of bystander versus adaptive response: Lessons from the microbeam studies.
Int. Congress Series 1236:241-247 (2002).[abstract]
Amundson S.A., Bittner M., Meltzer P., Trent J. and Fornace A.J., Jr.
Biological indicators for the identification of ionizing radiation
exposure in humans. Expert Rev Mol Diagn 1:211-219 (2001). [abstract]
Amundson S.A. and Fornace A.J., Jr. Gene expression profiles for
monitoring radiation exposure. Radiat Prot Dosimetry 97:11-16
(2001). [abstract]
Milligan J.R., Aguilera J.A.,
Paglinawan R.A., Ward J.F. and Limoli. C.L. DNA strand break yields after
post-high LET irradiation incubation with endonuclease-III and evidence
forhydroxyl radical clustering. Int. J. Radiat. Biol. 77:155-164
(2001). [abstract]
[PDF]
Zhou H., Suzuki M.,
Randers-Pehrson G., Vannais D., Chen G., Trosko J.E., Waldren C.A., Hei
T.K. Radiation risk to low fluences of alpha particles may be greater than
we thought. Proc. Natl. Acad. Sci. USA 98:14410-14415
(2001). [abstract]
[PDF]
Miller R.C., Marino, S.A.,
Napoli J., Shah H., Hall, E.J., Geard C.R. and Brenner D.J. Oncogenic
transformation in C3H10T˝ cells by low-energy neutrons. Int. J. Radiat.
Biol. 76:327-334 (2000). [abstract]
[PDF]
Zhou H., Randers-Pehrson G.,
Waldren C.A., Vannais D., Hall E.J. and Hei T.K. Induction of a bystander
mutagenic effect of alpha particles in mammalian cells. Proc. Natl.
Acad. Sci. USA 97:2099-2104, 2000. [abstract]
[PDF]
Miller R.C., Marino S.A.,
Martin S.G., Komatsu K., Geard C.R., Brenner D.J. and Hall E.J.
Neutron-energy-dependent cell survival and oncogenic transformation. J.
Radiat. Res. 40:53-59 Suppl (1999). [abstract]
[PDF]
Piao C.Q., Willey J.C. and
Hei T.K. Alterations of p53 in tumorigenic human bronchial epithelial
cells correlate with metastatic potential. Carcinogenesis 20:1529-1533
(1999). [abstract]
[PDF]
Wu L.J., Randers-Pehrson G.,
Xu A., Waldren C.A., Geard C.R., Yu Z. and Hei T.K. Targeted cytoplasmic
irradiation with alpha particles induces mutations in mammalian cells.
Proc Natl Acad Sci USA 96:4959-4964 (1999). [abstract]
[PDF]
Hei T.K., Wu L.J., Liu S.X.,
Vannais D, Waldren C.A. and Randers-Pehrson G. Mutagenic effects of a
single and an exact number of a particles in mammalian cells. Proc.
Natl. Acad. Sci. USA 94:3765-3770 (1997). [abstract]
[PDF]
Weaver D.A., Hei T.K., Hukku
B., McRaven J.A.M. and Willey J.A. Cytogenetic and molecular genetic analysis
of tumorigenic human bronchial epithelial cells induced by radon alpha
particles. Carcinogenesis 18:1251-1257 (1997). [abstract]
Biology articles originated by Columbia scientists
Hei T.K., Ballas L.K., Brenner D.J., Geard C.R. Advances in radiobiological
studies using a microbeam. J. Radiat. Res. 50 Suppl.
A:A7-A12 (2009). [abstract]
[PDF]
Ghandhi S.A., Yaghoubian B. and Amundson S.A. Global gene expression
analyses of bystander and alpha particle irradiated normal human lung
fibroblasts: Synchronous and differential responses. BMC Med Genomics.
1: 63 (2008). [abstract]
[PDF]
Hei T.K., Zhou H., Ivanov V.N., Hong M., Lieberman H.B., Brenner D.J.,
Amundson S.A. and Geard C.R. Mechanism of radiation-induced bystander
effects: a unifying model. J Pharm Pharmacol. 60:
943-950 (2008). [abstract]
[PDF]
Zhou H., Ivanov V.N., Lien Y.C., Davidson M. and Hei T.K. Mitochondrial
function and nuclear factor-kappaB-mediated signaling in radiation-induced
bystander effects. Cancer Res. 68: 2233-2240
(2008). [abstract]
[PDF]
Ivanov V.N., Zhou H. and Hei T.K. Sequential treatment by ionizing radiation
and sodium arsenite dramatically accelerates TRAIL-mediated apoptosis
of human melanoma cells. Cancer Res. 67: 5397-5407
(2007). [abstract]
[PDF]
Hei T.K., Radiation-Induced Bystander Effects: Mechanisms and Implication
for Low-Dose Radiation Risk Assessment. Radiat. Res. 167:
347-348 (2007).
Hei T.K., Zhou H.Z., Lien Y.C., and Zhao Y.L., Mechanism of radiation
carcinogenesis: BigH3, COX-2 and beyond. Int. Congress Series
1299: 114-120 (2007).
Ivanov V.N., Zhou H., and Hei T.K. Sequential treatment by ionizing radiation
and sodium arsenite dramatically accelerates trail-mediated apoptosis
of human melanoma cells. Cancer Res. 67: 5397-5407
(2007).[abstract]
[PDF]
Ponnaiya B, Jenkins-Baker G., Randers-Pherson G., and Geard CR. Quantifying
a bystander response following microbeam irradiation using single-cell
RT-PCR analyses. Exp. Hematol. 35(4 Suppl 1):
64-68 (2007).[abstract]
[PDF]
Calaf G.M., Roy D., Hei T.K. Growth factor biomarkers associated with
estrogen- and radiation-induced breast cancer progression. Int. J.
Oncol. 28:87-93 (2006). [PDF]
Hei T.K. Cyclooxygenase-2 as a signaling molecule in
radiation induced bystander effect. Mol. Carcinogenesis 45:455-460
(2006). [abstract]
[PDF]
Belyakov O.V., Mitchell S.A., Parikh D.,
Randers-Pehrson G., Marino S.A., Amundson S.A., Geard C.R. and Brenner D.J.
Biological effects in unirradiated human tissue induced by radiation
damage up to 1 mm away. Proc Natl Acad Sci U S A 102:14203-14208
(2005). [abstract]
[PDF]
Calaf G.M., Roy D. and Hei T.K. Immunochemical analysis of protein
expression in breast epithelial cells transformed by estrogens and high
linear energy transfer (LET) radiation Histochem. Cell Biol. 124:261-274
(2005). [PDF]
Persaud R., Zhou H., Baker S.E., Hei T.K. and Hall
E.J. Assessment of low linear energy transfer radiation-induced bystander
mutagenesis in a three-dimensional culture model. Cancer Res 65:9876-82
(2005). [abstract]
[PDF]
Smilenov L.B., Lieberman H.B., Mitchell S.A., Baker
R.A., Hopkins K.M. and Hall E.J. Combined haploinsufficiency for ATM and
RAD9 as a factor in cell transformation, apoptosis, and DNA lesion repair
dynamics. Cancer Res 65:933-938 (2005).
[abstract]
[PDF]
Zhou H., Ivanov V.N., Gillespie J., Geard C.R., Amundson S.A., Brenner
D.J., Yu Z., Lieberman H.B., and Hei T.K. Mechanism of radiation-induced
bystander effect: role of the cyclooxygenase-2 signaling pathway. Proc
Natl Acad Sci U S A, 102:14641-14646 (2005). [abstract]
[PDF]
Zhu A., Zhou H., Leloup C., Marino S.A., Geard C.R., Hei T.K. and Lieberman
H.B. Differential impact of mouse Rad9 deletion on ionizing radiation-induced
bystander effects. Radiat Res 164:655-661 (2005). [abstract]
[PDF]
Balajee A.S. and Geard C.R.
Replication protein A and gamma-H2AX foci assembly is triggered by
cellular response to DNA double-strand breaks. Exp. Cell. Res.
300:320-334 (2004). [abstract]
[PDF]
Balajee A.S., Ponnaiya B.,
Baskar R. and Geard C.R. Induction of replication protein a in bystander
cells. Radiat. Res. 162:677-686 (2004). [abstract]
[PDF]
Brenner D.J. Comments on "Chromosome intrachanges and interchanges
detected by multicolor banding in lymphocytes: Searching for clastogen
signatures in the human genome" by Johannes et al. (Radiat. Res.
161:540-548, 2004). Radiat Res 162:600; author reply 601
(2004). [PDF]
Calaf G.M. and Hei T.K. Ionizing radiation induces
alterations in cellular proliferation and c-myc, c-jun and c-fos protein
expression in breast epithelial cells. Int J Oncol 25:1859-1866
(2004). [abstract]
Geard C.R. and Ponnaiya B. Chromosomal changes and cell
cycle checkpoints in Mammalian cells. Methods Mol. Biol. 241:315-328
(2004).
Hei T.K., Persaud R., Zhou H.
and Suzuki M. Genotoxicity in the eyes of bystander cells. Mutat. Res.
568:111-120 (2004). [abstract]
[PDF]
Mitchell S.A., Randers-Pehrson G., Brenner D.J. and Hall
E.J. The Bystander Response in C3H 10T(1/2) Cells: The Influence of
Cell-to-Cell Contact. Radiat. Res. 161:397-401
(2004). [abstract]
[PDF]
Ponnaiya B, Jenkins-Baker G,
Bigelow A, Marino S and Geard CR. Detection of chromosomal instability in
alpha-irradiated and bystander human fibroblasts. Mutat. Res.
568:41-8 (2004). [abstract]
[PDF]
Ponnaiya G, Jenkins-Baker G,
Brenner DJ, Hall EJ, Randers-Pherson G and Geard CR. Biological responses
in known bystander cells, relative to known microbeam irradiated cells.
Radiat. Res. 162:426-432 (2004). [abstract]
[PDF]
Suzuki M., Zhou H., Geard
C.R. and Hei T.K. Effect of medium on chromatin damage in bystander
mammalian cells. Radiat. Res. 162:264-269 (2004). [abstract]
[PDF]
Hall E.J. The bystander effect. Health Physics
85:31-35 (2003). [abstract]
[PDF]
Hall E.J. and Hei T.K. Genomic instability and bystander
effects induced by high-LET radiation. Oncogene 22:7034-7042
(2003). [abstract]
[PDF]
Suzuki M., Zhou H., Hei T.K.,
Tsuruoka C. and Fujitaka K. Induction of a bystander chromosomal damage of
He-ion microbeams in mammalian cells. Biol. Sci. Space 17:251-252
(2003). [abstract]
Zhou H., Randers-Pehrson G., Geard C.R., Brenner D.J.,
Hall E.J. and Hei T.K. Interaction between radiation-induced adaptive
response and bystander mutagenesis in mammalian cells. Radiation
Research 160:512-516 (2003). [abstract]
[PDF]
Brenner D.J., Sawant S.G., Hande M.P., Miller R.C., Elliston
C.D., Fu Z., Randers-Pehrson G., and Marino S.A. Routine screening mammography:
how important is the radiation-risk side of the benefit-risk equation?
Int J Radiat Biol. 78:1065-1067 (2002). [abstract]
[PDF]
Geard C.R., Ponnaiya B., Jenkins-Baker G., Hei T.K., Brenner D.J., Hall
E.J. and Randers-Pehrson G. Microbeam mediated cellular effects:
Observations and implications for low dose radiation risk assessment. In
Molecular Mechanisms for Radiation-induced Cellular Response and Cancer
Development (Tanaka, K., Takabataka, T., Fujikawa, K., Matsumoto, T.
and Sato, F., Eds.), Institute for Environmental Science, Japan, p. 82-88
(2002).
Geard C.R., Jenkins-Baker G.,
Marino S.A. and Ponnaiya B. Novel approaches with track segment alpha
particles and cell co-cultures in studies of Bystander Effects. Radiat.
Prot. Dosim. 99:233-236 (2002). [abstract]
Sawant S.G., Zheng W.,
Hopkins K.M., Randers-Pehrson G., Lieberman H.B. and Hall E.J. The
radiation-induced bystander effect for clonogenic survival. Radiat.
Res. 157:361-364 (2002). [abstract]
[PDF]
Balajee A.S. and Geard C.R.
Chromatin bound PCNA complex formation triggered by DNA damage occurs
independent of the ATM gene product in human cells. Nucleic Acids Res.
29:1341-1351 (2001). [abstract]
[PDF]
Calaf G.M. and Hei T.K.
Oncoprotein expression in human breast epithelial cells transformed by
high LET radiation. Int. J. Radiat. Biol. 77:31-40 (2001). [abstract]
[PDF]
Hall E.J. Genomic
instability, bystander effect, cytoplasmic irradiation and other phenomena
that may achieve fame without fortune. Phys. Med. 17 Suppl 1:21-25
(2001). [abstract]
Hei T.K., Zhao Y.L., Roy D.,
Piao C.Q., Calaf G. and Hall E.J. Molecular alterations in tumorigenic
human bronchial and breast epithelial cells transformed by ionizing
radiation. Adv. Space Res. 27:411-419 (2001). [abstract]
[PDF]
Piao C.Q. and Hei T.K. Gene
amplification and microsatellite instability induced tumorigenic human
bronchial epithelial cells by alpha particles and heavy ions. Radiat.
Res. 155:263-267 (2001). [abstract]
[PDF]
Roy D., Calaf G. and Hei T.K.
Frequent allelic imbalance on chromosome 6 and 17 correlate with
radiation-induced neoplastic transformation of human breast epithelial
cells. Carcinogenesis Oct;22(10):1685-1692 (2001). [abstract]
[PDF]
Roy D., Calaf G. and Hei T.K.
Profiling of differentially expressed genes induced by high linear energy
transfer radiation in breast epithelial cells. Mol. Carcinog.
Aug;31(4):192-203 (2001). [abstract]
[PDF]
Sawant S.G., Randers-Pehrson
G., Metting, N. and Hall E.J. Adaptive response and the bystander effect
induced by radiation in C3H 10T(1/2) cells in culture. Radiat. Res.
156:177-180 (2001). [abstract]
[PDF]
Sawant S.G., Randers-Pehrson
G., Geard C.R., Brenner D.J. and Hall E.J. The bystander effect in
radiation oncogenesis I. Transformation in C3H 10T1/2 cells in vitro
can be initiated in the unirradiated neighbors of irradiated cells.
Radiat. Res. 155:397-401 (2001). [abstract]
[PDF]
Zhao Y.L., Piao C.Q., Hall
E.J. and Hei T.K. Mechanisms of radiation-induced neoplastic
transformation of human bronchial epithelial cells. Radiat. Res.
155:230-234 (2001). [abstract]
[PDF]
Calaf G.M. and Hei T.K.
Establishment of a radiation- and estrogen-induced breast cancer model.
Carcinogenesis 21:769-776 (2000). [abstract]
[PDF]
Geard C.R., Randers-Pehrson G., Marino S.A., Jenkins-Baker
G., Hei T.K., Hall E.J. and Brenner D.J. Intra- and inter-cellular
responses following cell-site specific microbeam irradiation. Radiat.
Res. 153:233 (2000). [PDF]
Hei T.K., Roy D., Piao C.Q.,
Calaf G. and Hall E.J. Genomic instability in human epithelial cells
transformed by high LET radiation. In: Proceedings of Radiation
Research (Moriarty M., Mothersill C., Seymour C., Edington M., Ward
J.F. and Fry R.J.M., Eds.), pp. 560-563, Allen Press, Lawrence, KS (2000).
Hei T.K., Zhou H.N., Wu L.X.,
Randers-Pehrson G., Waldren C. and Geard C.R. Radiation induced genotoxic
damage: From cytoplasm to nucleus and the bystander phenomenon. In:
Free Radicals in Chemistry, Biology and Medicine (Yoshikawa T.,
Toyokuni S., Naito Y. and Yamamoto Y., Eds.), pp. 241-247, OICA
International Press, London (2000).
Miller R.C., Sawant S.G., Randers-Pehrson
G., Marino S.A., Geard C.R., Hall E.J. and Brenner D.J. Single
alpha-particle traversals and tumor promoters. Radiation Research
153:227 (2000). [PDF]
Zhou H., Randers-Pehrson G. and Hei T.K.
Studies of bystander mutagenic response using a charged particle microbeam.
Radiation Research 153:234-235 (2000).
[PDF]
Miller R.C., Randers-Pehrson
G., Geard C.R., Hall E.J., and Brenner D.J. The oncogenic transforming
potential of the passage of single alpha particles through mammalian cell
nuclei. Proc. Nat. Acad. Sci. USA 96:19-22
(1999). [abstract]
[PDF]
Miller R.C., Martin S.G.,
Geard C.R., Marino S.A., Randers-Pehrson G., Brenner D.J. and Hall E.J.
High LET-induced oncogenic transformation. In: Risk Evaluation of
Cosmic-ray Exposure in Long-term Manned Space Mission (Fujitaka, et
al., Eds.) pp. 121-126, Kondasha Scientific Ltd., Tokyo, Japan (1999).
Zhou H., Zhu L.X., Li K. and
Hei T.K. Radon, tobacco-specific nitrosamine and mutagenesis in mammalian
cells. Mutat. Res. 430:145-153 (1999). [abstract]
[PDF]
Hei T.K., Piao C.Q., Wu L.X.,
Willey J.C. and Hall E.J. Genomic instability and tumorigenesis induction
in immortalized human bronchial cells by heavy ions. Adv. Space Res.
22:1699-1707 (1998). [abstract]
[PDF]
Miller R.C., Martin S.G.,
Hanson W.R., Marino S.A. and Hall E.J. Effect of track structure and
radioprotectors on the induction of oncogenic transformation in murine
fibroblasts by heavy ions. Adv. Space Res. 22:1719-1723
(1998). [abstract]
[PDF]
Geard C.R., Randers-Pehrson
G., Hei T.K., Jenkins G.J., Miller R.C., Wu L.J., Brenner D.J. and Hall
E.J. Microbeam mediated cellular effects: Single alpha particle induced
chromosomal damage, cell cycle delay, mutation and oncogenic transformation.
In: Microdosimetry, An interdisciplinary approach (Goodhead D.T.,
O’Neill P. and Menzel H.G., Eds.), pp327-330 (1997).
Physics articles involving outside users
Bigelow A.W., Garty G., Funayama T., Randers-Pehrson G., Brenner D.J.
and Geard C. Expanding the Question-answering Potential of Single-cell
Microbeams at RARAF, USA. J. Radiat. Res. 50:
Suppl., A21-A28, 2009. [PDF]
Shuryak I., Sachs R.K. and Brenner D.J. Biophysical models of radiation
bystander effects: 1. Spatial effects in three-dimensional tissues.
Radiat Res. 168: 741-749 (2007).[abstract]
[PDF]
Nikolaev A., Oks E.M., Savkin K., Yushkov G.Yu., Brenner, D.J. Johnson
G., Randers-Pehrson G., Brown I.G. and MacGill R.A. Surface resistivity
tailoring of ceramic insulators for an ion microprobe application. Surf.
Coat. Tech 201: 8120-8122 (2007).[PDF]
Sykora G.J., Akselrod M.S., Salasky M., Marino S.A., Novel Al2O3:C,
Mg Fluorescent Nuclear Track Detectors for Passive Neutron Dosimetry,
Radiat. Prot. Dosim. 126: 278-283 (2007).[abstract]
[PDF]
Shuryak I., Sachs R.K., Hlatky L., Little M.P., Hahnfeldt P., Brenner
D.J., Radiation-induced leukemia at doses relevant to radiation therapy:
modeling mechanisms and estimating risks. J Natl Cancer Inst.
98:1794-1806 (2006).[abstract]
[PDF]
Brenner D.J., Sachs R.K., Estimating radiation-induced cancer risks at
very low doses: rationale for using a linear no-threshold approach. Radiat.
Environ. Biophys. 44: 253-256 (2006).[abstract]
[PDF]
Maurer, R.H., Roth, D.R., Kinnison, J.D., Haggerty, D.K. and Goldsten,
J.O. The NSBRI/APL Neutron Energy Spectrometer. Johns Hopkins APL
Technical Digest 27: 56-65 (2006).[PDF]
Aprile E., Giboni K.L., Majewski P., Ni K., Yamashita M., Hasty R., Manzur
A. and McKinsey D.N. Scitillation response of liquid Xenon to low energy
nuclear recoils. Phys. Rev. D 72:072006 (2005). [PDF]
Maurer R.H., Zeitlin C.J., Haggerty D.K., Roth D.R. and Goldsten J.O.
Compact ion and neutron spectrometer (CINS) for space application. 2005
IEEE Nuclear Science Symposium Conference Record, N14-48, pp. 428-432,
Puerto Rico, 23-29 October 2005.[PDF]
Sachs R.K. and Brenner D.J. Solid tumor risks after high doses of
ionizing radiation. Proc. Natl. Acad. Sci. USA 102:13040-13045
(2005). [abstract]
[PDF]
Brenner D.J. and Sachs R.K. Domestic radon risks may be dominated by
bystander effects – but the risks are unlikely to be greater than we thought.
Health Phys. 85:103-108 (2003). [abstract]
[PDF]
Maurer RH, Roth DR, Kinnison JD, Goldsten
JO, Gold RE and Fainchtein R. MArs Neutron Energy Spectrometer (MANES):
An instrument for the Mars 2003 Lander. Acta Astronaut. 52:405-410
(2003). [abstract]
[PDF]
Horowitz Y.S., Oster L., Biderman S. and
Einav Y. Localized transitions in the thermoluminescence of LiF:Mg,Ti:potential
for nanoscale dosimetry. J. Phys. D. Appl. Phys. 36:446-459
(2003). [abstract]
[PDF]
Kinnison J.D., Maurer R.H., Roth D.R. and
Haight R. C. High energy neutron spectroscopy with thick silicon
detectors. Radiat. Res. 159:154-160 (2003). [abstract]
[PDF]
Brenner D.J. and Sachs R.K.
Do low dose-rate bystander effects influence domestic radon risks? Int.
J. Radiat. Biol. 78:593-604 (2002). [abstract]
[PDF]
Brenner D.J., Little J.B. and
Sachs R.K. The bystander effect in radiation oncogenesis II. A
quantitative model. Radiat. Res. 155:402-408 (2001). [abstract]
[PDF]
Maurer R.H., Kinnison J.D., Roth D.R. and
Goldsten J.O. Neutron spectroscopy on the international space station,
AIAA Conference on International Space Station Utilization, Cape
Canaveral, FL, 16 October, 2001. Proceedings published on CD ROM (AIAA
paper 2001-5059).
Ponomarev A.L., Cucinotta F.A., Sachs R.K.
and Brenner D.J. Monte Carlo predictions of DNA fragment-size
distributions for large sizes after HZE particle irradiation. Phys.
Med. 17 Suppl 1:153-156 (2001). [abstract]
Ponomarev A.L., Cucinotta F.A.,
Sachs R.K., Brenner D.J. and Peterson L.E. Extrapolation of the DNA
fragment-size distribution after high-dose irradiation to predict effects
at low doses. Radiat. Res. 156:594-597 (2001). [abstract]
[PDF]
Hong J., Craig W.W. and
Hailey C.J. Laboratory tests on neutron shields for gamma-ray detectors in
space. Nucl. Instrum. Methods Phys. Res. A 452:192-204
(2000).
[PDF]
Maurer R.H., Roth D.R., Fainchtein R.,
Goldsten J.O. and Kinnison, J.D. Portable real time neutron
spectrometry II, Proceedings of the International Space Station
Conference, Albuquerque, NM, January 30-February 3, 2000.
Ponomarev A.L., Brenner D.J.,
Hlatky L.R., and Sachs R.K. A polymer, random walk model for the
size-distribution of large DNA fragments after high linear energy transfer
radiation. Radiat. Environ. Biophys. 39:111-120
(2000). [abstract]
[PDF]
Le B.Q., Maurer R.H., Nhan
E. and Lew A. Design, fabrication, and qualification of chip-on-board
technology for space electronics. Int. J. Microcircuits Electron. Packag.
(USA) 22:104-114 (1999).
Hong J., Hailey C.J. and Craig
W.W. Development of neutron shields in gamma-ray detectors. In: Proceedings
of the SPIE, 3445 (Siegmund O. and Gunmin M., Eds.), pp. 121-131 (1998).
[PDF]
Obelic B., Srdoc D., Djuric
P.M. and Marino S.A. The frequency distribution of the number of ion pairs
in irradiated tissue. Radiat. Res. 149:411-415 (1998). [abstract]
Azziz N., Ranogajec-Komor M.,
Marino S.A., Klemic G.A. and Osvay M. Fast neutron detection using aluminum
oxide TLDs. In Proc. of the IRPA Regional Symposium on Radiation Protection
in Neighboring Countries of Central Europe (J. Sabol, Ed.) pp. 495-497,
Prague, Czech Republic (1997).
Physics articles originated by
Columbia scientists
Bigelow A.W., Geard C.R., Randers-Pehrson G. and Brenner D.J. Microbeam-integrated
multiphoton imaging system. Rev. Sci. Instrum. 79:123707
(2008). [PDF]
Bigelow A.W., Brenner D.J., Garty G. and Randers-Pehrson G.
Single-particle/single-cell ion microbeams as probes of biological
mechanisms. IEEE Trans. Plasma Sci. 36:1424-1431 (2008). [PDF]
Garty G., Ross G.J., Bigelow A., Randers-Pehrson G. and Brenner D.J.
Testing the stand-alone microbeam at Columbia University. Radiat. Prot.
Dosim. epub (2006). [PDF]
Bigelow A., Ross G., Randers-Pehrson G. and Brenner DJ. The Columbia
University Microbeam II endstation for cell imaging and irradiation.
Nucl Instr Meth B 231:202-206 (2005). [PDF]
Bigelow, A.W., Randers-Pehrson, G., Kelly, R.P. and Brenner, D.J.
Laser Ion Source for Columbia University’s Microbeam. Nucl. Instr.
Meth. B 241: 874-879 (2005). [PDF]
Garty G., Randers-Pehrson G. and Brenner D.J. Development
of a secondary-electron ion-microscope for microbeam diagnostics. Nucl
Instr Meth B 231:60-64 (2005). [PDF]
Garty G., Ross G.J., Bigelow A., Randers-Pehrson G. and
Brenner D.J. A microbeam irradiator without an accelerator.
Nucl. Instrum. Meth. B 241:392-396 (2005). [PDF]
Ross G.J., Bigelow,A.W., Randers-Pehrson G., Peng C.C.
and Brenner D.J. Phase-based cell imaging techniques for microbeam irradiations.
Nucl Instr Meth B241: 387-391 (2005). [PDF]
Ross G., Garty G., Randers-Pehrson G. and Brenner D.J. A
single-particle/single-cell microbeam based on an isotopic alpha source.
Nucl Instr Meth B 231:207-211 (2005). [PDF]
Bigelow A.W., Randers-Pehrson G. and Brenner D.J. Proposed
laser ion source for the Columbia University microbeam. Nucl. Instr.
Meth. B 210:65-69 (2003). [PDF]
Bigelow A.W., Randers-Pehrson
G. and Brenner D.J. Laser ion source development for the Columbia
University microbeam. Rev. Sci. Instrum. 73:770-772 (2002).
[abstract]
[PDF]
Randers-Pehrson G. Microbeams,
microdosimetry and specific dose. Radiat. Prot. Dosim. 99:471-472
(2002). [abstract]
Brenner D.J. and Elliston
C.D. The potential impact of the bystander effect on radiation risks in a
Mars mission. Radiat. Res. 156:612-617 (2001) [abstract]
[PDF]
Randers-Pehrson G., Geard
C.R., Johnson G., Elliston C.D. and Brenner D.J. The Columbia University
single-ion microbeam. Radiat. Res. 156:210-214 (2001). [abstract]
[PDF]
Dymnikov A.D., Brenner D.J., Johnson G.W. and Randers-Pehrson G.
Electrostatic lens design for the Columbia microbeam. Radiation
Research 153:236-237 (2000). [PDF]
Dymnikov A.D., Brenner D.J.,
Johnson G. and Randers-Pehrson G. Theoretical study of short electrostatic
lens for the Columbia ion microprobe. Rev. Sci. Instr. 71:1646-1650
(2000). [abstract]
[PDF]
Randers-Pehrson G., Geard C.R., Johnson
G.W. and Brenner D.J. Technical characteristics of the Columbia
University single-ion microbeam. Radiation Research 153:221-223
(2000). [PDF]
Randers-Pehrson G. and
Brenner D.J. A practical target system for accelerator-based BNCT which
may effectively double the dose rate. Med. Phys. 28:894-896
(1998). [abstract].
Published proceedings from workshops sponsored by RARAF
Proceedings of the 7th international workshop: Microbeam
probes of cellular radiation response. Radiat. Res.
166:652-689 (2006) [PDF 323
KB]
Proceedings of the 6th international workshop/12th L. H.
Gray workshop: Microbeam probes of cellular radiation response. Radiat.
Res. 161:87-119 (2004). [PDF
293 KB]
Proceedings of the 5th international
workshop: Microbeam probes of cellular radiation response. Radiat.
Res. 158:365-385 (2002). [PDF
190 KB]
Brenner D.J. and Hall E.J. Microbeams: A potent mix of physics
and biology. Summary of the 5th International Workshop on Microbeam Probes
of Cellular Radiation Response. Radiat Prot Dosimetry. 99:283-6
(2002). [abstract]
Extended Abstracts, Probing
individual cells: Applications to signaling, structure and function.
Radiat. Res. 156:434-445 (2001). [PDF
900 KB]
Proceedings of the 4th
international workshop: Microbeam probes of cellular radiation response.
Radiat. Res. 153:220-238 (2000). [PDF
226 KB]
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